Selected Publications
Perioperative pembrolizumab, trastuzumab and FLOT in HER2-positive localized esophagogastric adenocarcinoma: a phase 2 trial
Stein A, Goekkurt E, Al-Batran SE, Moosmann N, Ettrich TJ, Goetze T, Gruen B, Homann N, Lorenzen S, Hofheinz RD, Rempel V, Siegler G, Müller C, Thiele B, Broering T, Cruz MS, Pauligk C, Binder M, Tintelnot J.
Nat Med. 2025 Dec;31(12):4197-4204. doi: 10.1038/s41591-025-03979-y. Epub 2025 Oct 18.PMID: 41109919 Free PMC article. Clinical Trial.
Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages
Liebold I, Al Jawazneh A, Casar C, Lanzloth C, Leyk S, Hamley M, Wong MN, Kylies D, Gräfe SK, Edenhofer I, Aranda-Pardos I, Kriwet M, Haas H, Krause J, Hadjilaou A, Schromm AB, Richardt U, Eggert P, Tappe D, Weidemann SA, Ghosh S, Krebs CF, A-Gonzalez N, Worthmann A, Lohse AW, Huber S, Rothlin CV, Puelles VG, Jacobs T, Gagliani N*, Bosurgi L*
Science. 2024 Apr 5;384(6691):eabo7027. doi: 10.1126/science.abo7027. Epub 2024 Apr 5.PMID: 38574142
* co last authors
Short-term dietary changes can result in mucosal and systemic immune depression
Siracusa F#*, Schaltenberg N#, Kumar Y, Lesker TR, Steglich B, Liwinski T, Cortesi F, Frommann L, Diercks BP, Bönisch F, Fischer AW, Scognamiglio P, Pauly MJ, Casar C, Cohen Y, Pelczar P, Agalioti T, Delfs F, Worthmann A, Wahib R, Jagemann B, Mittrücker HW, Kretz O, Guse AH, Izbicki JR, Lassen KG, Strowig T, Schweizer M, Villablanca EJ, Elinav E, Huber S, Heeren J, Gagliani N*
# Co First authors
*Corresponding authors
Nat Immunol. 2023 Aug 14. doi: 10.1038/s41590-023-01587-x. Online ahead of print.
Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer
Tintelnot J*, Xu Y, Lesker TR, Schönlein M, Konczalla L, Giannou AD, Pelczar P, Kylies D, Puelles VG, Bielecka AA, Peschka M, Cortesi F, Riecken K, Jung M, Amend L, Bröring TS, Trajkovic-Arsic M, Siveke JT, Renné T, Zhang D, Boeck S, Strowig T, Uzunoglu FG, Güngör C, Stein A, Izbicki JR, Bokemeyer C, Sinn M, Kimmelman AC, Huber S#, Gagliani N*#
*Corresponding authors
# These authors cosuprevised equally to this work
Nature. 2023 Feb 22. doi: 10.1038/s41586-023-05728-y. PMID: 36813961
Efferocytosis fuels malignant pleural effusion through TIMP1
Lilan Zhao*, Anastasios D Giannou*, Yang Xu*, Ahmad Mustafa Shiri, Imke Liebold, Babett Steglich, Tanja Bedke, Tao Zhang, Jöran Lücke, Pasquale Scognamiglio, Jan Kempski, Anna Woestemeier, Jing Chen, Theodora Agalioti, Dimitra E Zazara, Diana Lindner, Melanie Janning, Jan K Hennigs, Rajesh M Jagirdar, Ourania S Kotsiou, Sotirios G Zarogiannis, Yasushi Kobayashi, Jacob R Izbicki, Sourav Ghosh, Carla V Rothlin, Lidia Bosurgi#, Samuel Huber#, Nicola Gagliani#
*These authors contributed equally to this work
# These authors cosuprevised equally to this work
Science Adv. 2021 Aug 13;7(33):eabd6734
Single-cell atlas of hepatic T cells reveals expansion of liver-resident naïve-like CD4+ T cells in primary sclerosing cholangitis
Tobias Poch*, Jenny Krause*, Christian Casar, Timur Liwinski, Laura Glau, Max Kaufmann, Annika E Ahrenstorf, Leonard U Hess, Annerose E Ziegler, Glòria Martrus, Sebastian Lunemann, Marcial Sebode, Jun Li, Dorothee Schwinge, Christian F Krebs, Andre Franke, Manuel A Friese, Karl J Oldhafer, Lutz Fischer, Marcus Altfeld, Ansgar W Lohse, Samuel Huber, Eva Tolosa#, Nicola Gagliani#^, Christoph Schramm#^
*These authors contributed equally to this work
#These authors shared senior authorship and ^these are the corresponding authors
J. Hepatol. 2021 Mar 24:S0168-8278(21)00219-1
Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients
Yu Zhao*, Christoph Kilian*, Jan-Eric Turner*, Lidia Bosurgi*, Kevin Roedl*, Patricia Bartsch, Ann-Christin Gnirck, Filippo Cortesi, Christoph Schultheiß, Malte Hellmig, Leon UB Enk, Fabian Hausmann, Alina Borchers, Milagros N Wong, Hans-Joachim Paust, Francesco Siracusa, Nicola Scheibel, Marissa Herrmann, Elisa Rosati, Petra Bacher, Dominik Kylies, Dominik Jarczak, Marc Lütgehetmann, Susanne Pfefferle, Stefan Steurer, Julian Schulze zur Wiesch, Victor G Puelles, Jan-Peter Sperhake, Marylyn M Addo, Ansgar W Lohse, Mascha Binder, Samuel Huber, Tobias B Huber, Stefan Kluge, Stefan Bonn, Ulf Panzer#, Nicola Gagliani #^, Christian F Krebs #^
*These authors contributed equally to this work
#These authors jointly directed this work and ^ these authors are the corresponding authors alphabetically ordered
Science Immunol. 2021 Feb 23;6(56):eabf6692
The induction and function of the anti-inflammatory fate of TH17 cells
Hao Xu*, Theodora Agalioti*, Jun Zhao, Babett Steglich, Ramez Wahib, Maria Carolina Amezcua Vesely, Piotr Bielecki, Will Bailis, Ruaidhri Jackson, Daniel Perez, Jakob Izbicki, Paula Licona-Limón, Vesa Kaartinen, Jens Geginat, Enric Esplugues, Eva Tolosa, Samuel Huber,
Richard A Flavell#, Nicola Gagliani#
*These authors contributed equally to this work
#These authors jointly directed this work and are the corresponding authors
Nat. Commun. 2020 Jul 3;11(1):3334
IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans
Jan Kempski*, Anastasios D Giannou*, Kristoffer Riecken, Lilan Zhao, Babett Steglich, Jöran Lücke, Laura Garcia-Perez, Karl-Frederick Karstens, Anna Wöstemeier, Mikolaj Nawrocki, Penelope Pelczar, Mario Witkowski, Sven Nilsson, Leonie Konczalla, Ahmad Mustafa Shiri, Joanna Kempska, Ramez Wahib, Leonie Brockmann, Philipp Huber, Ann-Christin Gnirck, Jan-Eric Turner, Dimitra E Zazara, Petra C Arck, Alexander Stein, Ronald Simon, Anne Daubmann, Jan Meiners, Daniel Perez, Till Strowig, Pandelakis Koni, Andrey A Kruglov, Guido Sauter, Jakob R Izbicki, Andreas H Guse, Thomas Rösch, Ansgar W Lohse, Richard A Flavell, Nicola Gagliani#, Samuel Huber#
*These authors contributed equally to this work
#These authors jointly directed this work and are the corresponding authors
Gastroenterology 2020 Oct;159(4):1417-1430.e3
Effector T(H)17 Cells Give Rise to Long-Lived T(RM) Cells that Are Essential for an Immediate Response against Bacterial Infection
Maria Carolina Amezcua Vesely, Paris Pallis, Piotr Bielecki, Jun Siong Low, Jun Zhao, Christian CD Harman, Lina Kroehling, Ruaidhrí Jackson, Will Bailis, Paula Licona-Limón, Hao Xu, Norifumi Iijima, Padmini S Pillai, Daniel H Kaplan, Casey T Weaver, Yuval Kluger, Monika S Kowalczyk, Akiko Iwasaki, Joao P Pereira, Enric Esplugues, Nicola Gagliani#, Richard A Flavell#
#These authors jointly directed this work and are the corresponding authors
Cell. 2019 Aug 22;178(5):1176-1188.e15
The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases
Maria Grazia Roncarolo, Silvia Gregori, Rosa Bacchetta, Manuela Battaglia, Nicola Gagliani
Immunity. 2018 Dec 18;49(6):1004-1019
A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease
Penelope Pelczar*, Mario Witkowski*, Laura Garcia Perez*, Jan Kempski, Anna G Hammel, Leonie Brockmann, Dörte Kleinschmidt, Sandra Wende, Cathleen Haueis, Tanja Bedke, Marco Witkowski, Susanne Krasemann, Stefan Steurer, Carmen J Booth, Philipp Busch, Alexandra König, Ursula Rauch, Daniel Benten, Jakob R Izbicki, Thomas Rösch, Ansgar W Lohse, Till Strowig, Nicola Gagliani#, Richard A Flavell#^, Samuel Huber#^
*These authors contributed equally to this work
# These authors jointly directed this work and ^these authors are the corresponding authors
Science. 2016 Oct 21;354(6310):358-362
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
Nicola Gagliani, Maria Carolina Amezcua Vesely, Andrea Iseppon, Leonie Brockmann, Hao Xu, Noah W Palm, Marcel R De Zoete, Paula Licona-Limón, Ricardo S Paiva, Travers Ching, Casey Weaver, Xiaoyuan Zi, Xinghua Pan, Rong Fan, Lana X Garmire, Matthew J Cotton, Yotam Drier, Bradley Bernstein, Jens Geginat, Brigitta Stockinger, Enric Esplugues, Samuel Huber#, Richard A Flavell#
# These authors jointly directed this work
Nature. 2015 Jul 9;523(7559):221-5
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
Nicola Gagliani*, Chiara F Magnani*, Samuel Huber*, Monica E Gianolini, Mauro Pala, Paula Licona-Limon, Binggege Guo, De'Broski R Herbert, Alessandro Bulfone, Filippo Trentini, Clelia Di Serio, Rosa Bacchetta, Marco Andreani, Leonie Brockmann, Silvia Gregori#, Richard A Flavell#, Maria-Grazia Roncarolo#
*These authors contributed equally to this work
# These authors jointly directed this work
Nat Med. 2013 Jun;19(6):739-46
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
Samuel Huber*, Nicola Gagliani*, Lauren A Zenewicz, Francis J Huber, Lidia Bosurgi, Bo Hu, Matija Hedl, Wei Zhang, William O’Connor, Andrew J Murphy, David M Valenzuela, George D Yancopoulos, Carmen J Booth, Judy H Cho, Wenjun Ouyang, Clara Abraham, Richard A Flavell
*These authors contributed equally to this work
Nature, 2012 Nov 8;491(7423):259-63
Publications - AG Gagliani
Find publications from NICOLAB from our research information system or direct links to PubMed or Google Scholar.
PubMed - AG Gagliani | https://pubmed.ncbi.nlm.nih.gov/?term=Gagliani+Nicola&sort=date
Scholar Google - AG Gagliani | https://scholar.google.com/citations?user=GiQ7ktQAAAAJ&hl=en
